Digital economy to promote the transformation and upgrading of international trade strategy research

With the rapid development of social economy, a variety of advanced technologies and equipment have emerged, which ushered in the era of digital economy, and then promote the upgrade and transformation of international trade, the development goal is in line with the inherent requirements of the current international economic environment. In the context of digital economy, can further promote the international trade subject diversifi cation, diversifi cation of trade products, trade cost structure of the depth of development, it can be seen that the need to continue to invest manpower, material resources and funds to promote the eff ective integration of digital economy and international trade, and ultimately help the upgrade and transformation of international trade. How to further promote the transformation and upgrading of international trade with the help of the development of digital economy is an important issue for current researchers to solve. This paper will launch an in-depth exploration around this issue, so as to comprehensively promote the high-quality development of international trade

Clinicopathological Research and Expression of PTEN/PI3K/Akt Signaling Pathway in Non-small Cell Lung Cancer

Background and objective It has been known that abnormality of PTEN/PI3K/Akt signal pathway played an important role in initiation of some malignant tumors. The aim of this study is to examine the expression and clinicopathological significance of PTEN, PI3K and Akt in non-small cell lung cancer (NSCLC). Methods Expression levels of PTEN, PI3K and Akt protein were determined using immunohistochemistry S-P in 61 specimens of NSCLC with follow-up. Results ①The levels of PTEN protein was higher than that of control group, and levels of PI3K and Akt protein were lower than that of control group; ②Expression of PTEN and PI3K were related to histotype, clinical stage, lymphonode metastasis and survival rate; Expression of Akt was related to clinical stage, lymphonode metastasis and survival rate; ③The Cox Monovariable Analyses revealed that both smoking and negative expression of PTEN were the risking factors on the death of the NSCLC patients after surgery; ④The expression of PTEN protein was negatively correlated to that of PI3K and Akt respectively, while the expression of PI3K was positively correlated to that of Akt. Conclusion In NSCLC, the lack of PTEN induced up-regulation of PI3K and Akt, which demonstrated that PTEN/PI3K/Akt signaling pathway contributed to the tumorigenesis and development of NSCLC. They could be used as the indicators of prognosis and targets of therapy

Source Mechanism and Seismic Effect of Tangshan Earthquake

By analyzing the seismic mechanism of the Tangshan earthquake and its pattern of movement through the study of ground deformation and ground strain of the Tangshan earthquake area it is clear that the breeding and occurrence of this event are controlled by a long-term intense active fault zone. By the ground deformation, displacement, tectonic features and seismic effects after the event, this causative fault is known to be composed of a group of NNE trending right turn strike-slip faults and thus we call it the Tangshan active fault zone

Learning One-Class Hyperspectral Classifier from Positive and Unlabeled Data for Low Proportion Target

Hyperspectral imagery (HSI) one-class classification is aimed at identifying a single target class from the HSI by using only positive labels, which can significantly reduce the requirements for annotation. However, HSI one-class classification is far more challenging than HSI multi-class classification, due the lack of negative labels and the low target proportion, which are issues that have rarely been considered in the previous HSI classification studies. In this paper, a weakly supervised HSI one-class classifier, namely HOneCls is proposed to solve the problem of under-fitting of the positive class occurs in the HSI data with low target proportion, where a risk estimator -- the One-Class Risk Estimator -- is particularly introduced to make the full convolutional neural network (FCN) with the ability of one class classification. The experimental results obtained on challenging hyperspectral classification datasets, which includes 20 kinds of ground objects with very similar spectra, demonstrate the efficiency and feasibility of the proposed One-Class Risk Estimator. Compared with the state-of-the-art one-class classifiers, the F1-score is improved significantly in the HSI data with low target proportion

硫酸氢氯吡格雷联合西洛他唑治疗糖尿病四肢并发症的临床疗效观察

Objective: To observe efficacy and safety of domestic clopidogrel cilostazol in treatment of diabetic limbs complications. Methods: 120 cases of diabetic patients with limb complications were randomly selected, including 60 cases of lower extremity arterial disease (PAD) and 60 patients with diabetic peripheral neuropathy (DPN) patients. According to the random number list, they were randomly divided into treatment group of 60 patients, DPN and PAD were given mecobalamin 0. 5mg / times , lipoic acid 500mg / d, alprostadil 10ug / d, DPN patients while giving epalrestat 50mg / times. The control group while giving cilostazol 0.1g, 2 times / d, plus clopidogrel treatment groups 150mg / d in the control group, based on continuous treatment for 8 weeks. Clinical evaluation of the two groups was made and conduction velocity of MNCV and SNCV was compared. Results: Analysis of DPN subgroup showed that the treatment group was efficient (73.4% vs 46.7%, P = 0.035), total efficiency (93.3% vs 73.3%, P = 0.038) were significantly higher, PAD subgroup analysis showed the efficiency of the treatment group was (70% vs 43.3%, P = 0.035), total efficiency (93.3% vs 73.3%, P = 0.038) were significantly higher. MNCV CKS nerve (54.3 ± 4.8 vs 50.5 ± 5.1) and the peroneal nerve (34.7 ± 3.2 vs 30.9 ± 3.4) conduction velocity improved more significantly. SNCV CKS nerve (43.4 ± 4.9 vs 38.2 ± 3.8) and the peroneal nerve (35.1 ± 5.6 vs 32.9 ± 5.4) conduction velocity, the treatment group improved significantly than the control group. PAD subgroup analysis, ABI degree of improvement (0.9 ± 0.3 vs 0.8 ± 0.3), dorsal blood flow (35.2±3.6 vs31.5±4.2), popliteal artery blood flow (64.2±5.6 vs 58.4±7.4) were better than the control group. Compared with clopidogrel, cilostazol did not increase in adverse events during treatment process. Conclusion: Clopidogrel cilostazol treatment of diabetic limb complications becomes safe and effective treatment of DPN and PAD, which can be used as a combination therapy.目的  观察国产氯吡格雷联合西洛他唑治疗糖尿病四肢并发症的有效性及安全性。方法  随机入选120例糖尿病四肢并发症患者，其中糖尿病周围神经病变（DPN）患者60例，下肢动脉病变（PAD）60例。按照随机数列表，随机分为治疗组60例，DPN及PAD均给予甲钴胺0. 5mg /次，硫辛酸500mg/d，前列地尔10ug/d，DPN患者同时给予依帕司他50mg /次。对照组同时给予西洛他唑0.1g，2次/d，治疗组在对照组基础上加上氯吡格雷首次600mg，后150mg/d连续7d，后改为75mg/d连续8周。评价两组的临床疗效及MNCV和SNCV传导速度。结果  DPN亚组分析显示，治疗组显效率（73.4% vs 46.7%, P=0.035）、总有效率（93.3% vs 73.3%，P=0.038）显著高于对照组，PAD亚组分析显示，治疗组显效率（70% vs 43.3%, P=0.035）、总有效率（93.3% vs 73.3%，P=0.038）显著高于对照组。MNCV中正中神经（54.3±4.8 vs 50.5±5.1）及腓总神经（34.7±3.2 vs 30.9±3.4）传导速度改善更为明显。SNCV中正中神经（43.4±4.9 vs 38.2±3.8）及腓总神经(35.1±5.6 vs 32.9±5.4)传导速度，治疗组改善亦较对照组更明显。PAD亚组分析显示，ABI改善程度（0.9±0.3 vs 0.8±0.3）、足背动脉血流速度（35.2±3.6 vs31.5±4.2），腘动脉血流量（64.2±5.6 vs 58.4±7.4）改善均优于对照组。治疗过程中氯吡格雷相比于西洛他唑并不增加不良事件。结论  氯吡格雷联合西洛他唑治疗糖尿病四肢并发症变安全、有效，可作为治疗DPN及PAD的联合治疗方案